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Review Article| Volume 33, ISSUE 4, P1045-1062, December 2019

Viral Hepatitis

Etiology, Epidemiology, Transmission, Diagnostics, Treatment, and Prevention

      Keywords

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      References

      1. Global hepatitis report 2017. World Health Organization, Geneva (Switzerland)2017 (Licence: CC BY-NC-SA 3.0 IGO. Available at:) (Accessed March 3, 2019)
      2. Global health sector strategy on viral hepatitis, 2016–2021. WHO, Geneva (Switzerland)2016 (WHO/HIV/2016.06. Available at:) (Accessed March 3, 2019)
        • Lanini S.
        • Easterbrook P.J.
        • Zumla A.
        • et al.
        Hepatitis C: global epidemiology and strategies for control.
        Clin Microbiol Infect. 2016; 22: 833-838
        • Najarian R.
        • Caput D.
        • Gee W.
        • et al.
        Primary structure and gene organization of human hepatitis A virus.
        Proc Natl Acad Sci U S A. 1985; 82: 2627-2631
        • Lemon S.M.
        • Ott J.J.
        • Van Damme P.
        • et al.
        Type A viral hepatitis: a summary and update on the molecular virology, epidemiology, pathogenesis and prevention.
        J Hepatol. 2018; 68: 167-184
        • Shin E.C.
        • Jeong S.H.
        Natural history, clinical manifestations, and pathogenesis of hepatitis A.
        Cold Spring Harb Perspect Med. 2018; 8: a031708
        • Hirai-Yuki A.
        • Hensley L.
        • McGivern D.R.
        • et al.
        MAVS-dependent host species range and pathogenicity of human hepatitis A virus.
        Science. 2016; 353: 1541-1545
        • McFarland N.
        • Dryden M.
        • Ramsay M.
        • et al.
        An outbreak of hepatitis A affecting a nursery school and a primary school.
        Epidemiol Infect. 2011; 139: 336-343
        • Matheny S.C.
        • Kingery J.E.
        Hepatitis A.
        Am Fam Physician. 2012; 86: 1027-1034
        • WHO
        WHO position paper on Hepatitis A vaccines.
        Wkly Epidiol Rec. 2012; 87: 15
        • GBD 2016 Causes of Death Collaborators
        Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.
        Lancet. 2017; 390: 1151-1210
        • Lanini S.
        • Pisapia R.
        • Capobianchi M.R.
        • et al.
        Global epidemiology of viral hepatitis and national needs for complete control.
        Expert Rev Anti Infect Ther. 2018; 16: 625-639
      3. World Health Organization Hepatitis 2018.
        (Available at:) (Accessed September 14, 2019)
        • Alventosa Mateu C.
        • Urquijo Ponce J.J.
        • Diago Madrid M.
        An outbreak of acute hepatitis due to the hepatitis A virus in 2017: are we witnessing a change in contagion risk factors?.
        Rev Esp Enferm Dig. 2018; 110: 675-676
        • Wang H.
        • Gao P.
        • Chen W.
        • et al.
        Changing epidemiological characteristics of Hepatitis A and warning of Anti-HAV immunity in Beijing, China: a comparison of prevalence from 1990 to 2017.
        Hum Vaccin Immunother. 2019; 15: 420-425
        • Croker C.
        • Hathaway S.
        • Marutani A.
        • et al.
        Outbreak of hepatitis A virus infection among adult patients of a mental hospital - Los Angeles County, 2017.
        Infect Control Hosp Epidemiol. 2018; 39: 881
        • Gassowski M.
        • Michaelis K.
        • Wenzel J.J.
        • et al.
        Two concurrent outbreaks of hepatitis A highlight the risk of infection for non-immune travellers to Morocco, January to June 2018.
        Euro Surveill. 2018; 23 (pii=1800329)
        • Viray M.A.
        • Hofmeister M.G.
        • Johnston D.I.
        • et al.
        Public health investigation and response to a hepatitis A outbreak from imported scallops consumed raw-Hawaii, 2016.
        Epidemiol Infect. 2018; 17: 1-8
        • Lanini S.
        • Minosse C.
        • Vairo F.
        • et al.
        A large ongoing outbreak of hepatitis A predominantly affecting young males in Lazio, Italy; August 2016 - March 2017.
        PLoS One. 2017; 12: e0185428
        • Foster M.
        • Ramachandran S.
        • Myatt K.
        • et al.
        Hepatitis A virus outbreaks associated with drug use and homelessness - California, Kentucky, Michigan, and Utah, 2017.
        MMWR Morb Mortal Wkly Rep. 2018; 67: 1208-1210
        • Lemon S.M.
        • Walker C.M.
        Enterically transmitted non-A, non-B Hepatitis and the discovery of hepatitis E virus.
        Cold Spring Harb Perspect Med. 2019; 9 ([pii:a033449])
        • Ott J.J.
        • Wiersma S.T.
        Single-dose administration of inactivated hepatitis A vaccination in the context of hepatitis A vaccine recommendations.
        Int J Infect Dis. 2013; 17: e939-e944
        • Souto F.J.D.
        • de Brito W.I.
        • Fontes C.J.F.
        Impact of the single-dose universal mass vaccination strategy against hepatitis A in Brazil.
        Vaccine. 2019; 37: 771-775
        • Joshi M.S.
        • Bhalla S.
        • Kalrao V.R.
        • et al.
        Exploring the concurrent presence of hepatitis A virus genome in serum, stool, saliva, and urine samples of hepatitis A patients.
        Diagn Microbiol Infect Dis. 2014; 78: 379-382
        • Nelson N.P.
        • Link-Gelles R.
        • Hofmeister M.G.
        • et al.
        Update: recommendations of the Advisory Committee on Immunization Practices for use of hepatitis A vaccine for postexposure prophylaxis and for preexposure prophylaxis for international travel.
        MMWR Morb Mortal Wkly Rep. 2018; 67: 1216-1220
        • Lin K.Y.
        • Chen G.J.
        • Lee Y.L.
        • et al.
        Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: a review.
        World J Gastroenterol. 2017; 23: 3589-3606
        • Link-Gelles R.
        • Hofmeister M.G.
        • Nelson N.P.
        Use of hepatitis A vaccine for post-exposure prophylaxis in individuals over 40 years of age: a systematic review of published studies and recommendations for vaccine use.
        Vaccine. 2018; 36: 2745-2750
        • Castillo E.M.
        • Chan T.C.
        • Tolia V.M.
        • et al.
        Effect of a computerized alert on emergency department hepatitis a vaccination in homeless patients during a large regional outbreak.
        J Emerg Med. 2018; 55: 764-768
        • Stuurman A.L.
        • Marano C.
        • Bunge E.M.
        • et al.
        Impact of universal mass vaccination with monovalent inactivated hepatitis A vaccines – A systematic review.
        Hum Vaccin Immunother. 2017; 13: 724-736
        • Victor J.C.
        • Monto A.S.
        • Surdina T.Y.
        • et al.
        Hepatitis A vaccine versus immune globulin for postexposure prophylaxis.
        N Engl J Med. 2007; 357: 1685-1694
        • Lin C.L.
        • Kao J.H.
        Natural history of acute and chronic hepatitis B: the role of HBV genotypes and mutants.
        Best Pract Res Clin Gastroenterol. 2017; 31: 249-255
        • Nguyen D.H.
        • Ludgate L.
        • Hu J.
        Hepatitis B virus-cell interactions and pathogenesis.
        J Cell Physiol. 2008; 216: 289-294
        • Tu T.
        • Budzinska M.A.
        • Shackel N.A.
        • et al.
        HBV DNA integration: molecular mechanisms and clinical implications.
        Viruses. 2017; 9: E75
        • Xiong Q.F.
        • Xiong T.
        • Huang P.
        • et al.
        Early predictors of acute hepatitis B progression to liver failure.
        PLoS One. 2018; 13: e0201049
        • European Association for the Study of the Liver
        EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.
        J Hepatol. 2017; 67: 370-398
        • Mikulska M.
        • Lanini S.
        • Gudiol C.
        • et al.
        ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52).
        Clin Microbiol Infect. 2018; 24: S71-S82
        • Smith D.B.
        • Bukh J.
        • Kuiken C.
        • et al.
        Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource.
        Hepatology. 2014; 59: 318-327
        • World Health Organization
        Hepatitis B vaccines: WHO position paper, July 2017 - recommendations.
        Vaccine. 2019; 37: 223-225
        • Chen H.Y.
        • Shen D.T.
        • Ji D.Z.
        • et al.
        Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis.
        Gut. 2019; 68: 512-521
        • Botelho-Souza L.F.
        • Vasconcelos M.P.A.
        • Dos Santos A.O.
        • et al.
        Hepatitis delta: virological and clinical aspects.
        Virol J. 2017; 14: 177
        • Murphy D.G.
        • Sablon E.
        • Chamberland J.
        • et al.
        Hepatitis C virus genotype 7, a new genotype originating from central Africa.
        J Clin Microbiol. 2015; 53: 967-972
        • Borgia S.M.
        • Hedskog C.
        • Parhy B.
        • et al.
        Identification of a novel hepatitis C virus genotype from Punjab, India: expanding classification of hepatitis C virus into 8 genotypes.
        J Infect Dis. 2018; 218: 1722-1729
        • Gasim G.I.
        • Bella A.
        • Adam I.
        Schistosomiasis, hepatitis B and hepatitis C co-infection.
        Virol J. 2015; 12: 19
        • Antonucci G.
        • Goletti D.
        • Lanini S.
        • et al.
        HIV/HCV co-infection: putting the pieces of the puzzle together.
        Cell Death Differ. 2003; 10: S25-S26
        • Lingala S.
        • Ghany M.G.
        Natural history of Hepatitis C.
        Gastroenterol Clin North Am. 2015; 44: 717-734
        • Sheer T.A.
        • Runyon B.A.
        Spontaneous bacterial peritonitis.
        Dig Dis. 2005; 23: 39-46
        • D'Amico G.
        • De Franchis R.
        Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators.
        Hepatology. 2003; 38: 599-612
        • Westbrook R.H.
        • Dusheiko G.
        Natural history of hepatitis C.
        J Hepatol. 2014; 61: S58-S68
        • Lanini S.
        • Scognamiglio P.
        • Pisapia R.
        • et al.
        Recovery of metabolic impairment of patients who cleared HCV infections after direct-acting antiviral therapy.
        Int J Antimicrob Agents. 2018; 53: 559-563
        • Younossi Z.
        • Park H.
        • Henry L.
        • et al.
        M. Extrahepatic manifestations of hepatitis C: a meta-analysis of prevalence, quality of life, and economic burden.
        Gastroenterology. 2016; 150: 1599-1608
        • Yeung C.Y.
        • Lee H.C.
        • Chan W.T.
        • et al.
        Vertical transmission of hepatitis C virus: current knowledge and perspectives.
        World J Hepatol. 2014; 6: 643-651
        • Messina J.P.
        • Humphreys I.
        • Flaxman A.
        • et al.
        Global distribution and prevalence of hepatitis C virus genotypes.
        Hepatology. 2015; 61: 77-87
        • Markov P.V.
        • van de Laar T.J.
        • Thomas X.V.
        • et al.
        Colonial history and contemporary transmission shape the genetic diversity of hepatitis C virus genotype 2 in Amsterdam.
        J Virol. 2012; 86: 7677-7687
        • Wasitthankasem R.
        • Vongpunsawad S.
        • Siripon N.
        • et al.
        Genotypic distribution of hepatitis C virus in Thailand and Southeast Asia.
        PLoS One. 2015; 10: e0126764
        • Li C.
        • Barnes E.
        • Newton P.N.
        • et al.
        An expanded taxonomy of hepatitis C virus genotype 6: characterization of 22 new full-length viral genomes.
        Virology. 2015; 476: 355-363
        • Strickland G.T.
        Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors.
        Hepatology. 2006; 43: 915-922
        • Al Naamani K.
        • Al Sinani S.
        • Deschênes M.
        Epidemiology and treatment of hepatitis C genotypes 5 and 6.
        Can J Gastroenterol. 2013; 27: e8-e12
        • Araujo A.C.
        • Astrakhantseva I.V.
        • Fields H.A.
        • et al.
        Distinguishing acute from chronic hepatitis C virus (HCV) infection based on antibody reactivities to specific HCV structural and nonstructural proteins.
        J Clin Microbiol. 2011; 49: 54-57
        • European Association for the Study of the Liver
        EASL recommendations on treatment of hepatitis C 2018.
        J Hepatol. 2018; 69: 461-511
      4. The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America Present HCV Guidance: recommendations for testing, managing, and treating hepatitis C.
        (Available at:) (Accessed September 14, 2019)
        • Nair V.P.
        • Anang S.
        • Subramani C.
        • et al.
        Endoplasmic reticulum stress induced synthesis of a novel viral factor mediates efficient replication of genotype-1 hepatitis E virus.
        PLoS Pathog. 2016; 12: e1005521
        • Yin X.
        • Li X.
        • Feng Z.
        Role of Envelopment in the HEV Life Cycle.
        Viruses. 2016; 8: E229
        • Cacoub P.
        • Desbois A.C.
        • Comarmond C.
        • et al.
        Impact of sustained virological response on the extrahepatic manifestations of chronic hepatitis C: a meta-analysis.
        Gut. 2018; 67: 2025-2034
        • Gentile I.
        • Scotto R.
        • Coppola C.
        • et al.
        Treatment with direct-acting antivirals improves the clinical outcome in patients with HCV-related decompensated cirrhosis: results from an Italian real-life cohort (Liver Network Activity-LINA cohort).
        Hepatol Int. 2019; 13: 66-74
        • Stournaras E.
        • Neokosmidis G.
        • Stogiannou D.
        • et al.
        Effects of antiviral treatment on the risk of hepatocellular cancer in patients with chronic viral hepatitis.
        Eur J Gastroenterol Hepatol. 2018; 30: 1277-1282
        • Kamar N.
        • Izopet J.
        • Pavio N.
        • et al.
        Hepatitis E virus infection.
        Nat Rev Dis Primers. 2017; 3: 17086
        • Chaudhry S.A.
        • Verma N.
        • Koren G.
        Hepatitis E infection during pregnancy.
        Can Fam Physician. 2015; 61: 607-608
        • Haffar S.
        • Shalimar
        • Kaur R.J.
        • et al.
        Acute liver failure caused by hepatitis E virus genotype 3 and 4: a systematic review and pooled analysis.
        Liver Int. 2018; 38: 1965-1973
        • Mclean B.N.
        • Gulliver J.
        • Dalton H.R.
        Hepatitis E virus and neurological disorders.
        Pract Neurol. 2017; 17: 282-288
        • European Association for the Study of the Liver
        EASL clinical practice guidelines on hepatitis E virus infection.
        J Hepatol. 2018; 68: 1256-1271
        • Su Y.Y.
        • Huang S.J.
        • Guo M.
        • et al.
        Persistence of antibodies acquired by natural hepatitis E virus infection and effects of vaccination.
        Clin Microbiol Infect. 2017; 23: 336.e1-4
        • Sooryanarain H.
        • Meng X.J.
        Hepatitis E virus: reasons for emergence in humans.
        Curr Opin Virol. 2018; 34: 10-17
        • Nan Y.
        • Wu C.
        • Zhao Q.
        • et al.
        Vaccine development against zoonotic hepatitis E virus: open questions and remaining challenges.
        Front Microbiol. 2018; 9: 266
        • Gurley E.S.
        • Hossain M.J.
        • Paul R.C.
        • et al.
        Outbreak of hepatitis E in urban Bangladesh resulting in maternal and perinatal mortality.
        Clin Infect Dis. 2014; 59: 658-665
        • Browne L.B.
        • Menkir Z.
        • Kahi V.
        • et al.
        Notes from the field: hepatitis E outbreak among refugees from South Sudan - Gambella, Ethiopia, April 2014-January 2015.
        MMWR Morb Mortal Wkly Rep. 2015; 64: 537
        • Wang B.
        • Akanbi O.A.
        • Harms D.
        • et al.
        A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017.
        Virol J. 2018; 15: 163
        • Spina A.
        • Lenglet A.
        • Beversluis D.
        • et al.
        A large outbreak of Hepatitis E virus genotype 1 infection in an urban setting in Chad likely linked to household level transmission factors, 2016-2017.
        PLoS One. 2017; 12: e0188240
      5. Hepatitis E vaccine: WHO position paper, May 2015.
        Wkly Epidemiol Rec. 2015; 90: 185-200
        • Sridhar S.
        • Teng J.L.L.
        • Chiu T.H.
        • et al.
        Hepatitis E virus genotypes and evolution: emergence of camel hepatitis E variants.
        Int J Mol Sci. 2017; 18: E869
        • Nimgaonkar I.
        • Ding Q.
        • Schwartz R.E.
        • et al.
        Hepatitis E virus: advances and challenges.
        Nat Rev Gastroenterol Hepatol. 2018; 15: 96-110
        • Izopet J.
        • Lhomme S.
        • Chapuy-Regaud S.
        • et al.
        HEV and transfusion-recipient risk.
        Transfus Clin Biol. 2017; 24: 176-181
        • Al-Sadeq D.W.
        • Majdalawieh A.F.
        • Mesleh A.G.
        • et al.
        Laboratory challenges in the diagnosis of hepatitis E virus.
        J Med Microbiol. 2018; 67: 466-480
        • Hartl J.
        • Otto B.
        • Madden R.G.
        • et al.
        Hepatitis E Seroprevalence in Europe: a meta-analysis.
        Viruses. 2016; 8: E211
        • van Eijk JJJ
        • Dalton H.R.
        • Ripellino P.
        • et al.
        Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy.
        Neurology. 2017; 89: 909-917
        • Fritz M.
        • Berger B.
        • Schemmerer M.
        • et al.
        Pathological cerebrospinal fluid findings in patients with neuralgic amyotrophy and acute hepatitis E virus infection.
        J Infect Dis. 2018; 217: 1897-1901
        • Todt D.
        • Meister T.L.
        • Steinmann E.
        Hepatitis E virus treatment and ribavirin therapy: viral mechanisms of nonresponse.
        Curr Opin Virol. 2018; 32: 80-87
        • WHO
        Hepatitis E vaccine: WHO position paper, May 2015--Recommendations.
        Vaccine. 2016; 34: 304-305